Eight ingredients.
Foundational support.

Coenzyme Q10 is a fat-soluble molecule that plays an indispensable role in mitochondrial energy production*. It is also a potent antioxidant. The heart, which beats approximately 100,000 times per day, is among the most CoQ10-dependent organs in the body.

Why it matters for statin users: Statin therapy uses the mevalonate pathway, which is responsible for synthesizing both cholesterol and CoQ10. Multiple studies confirm statin therapy reduces circulating CoQ10 levels by 16 to 54%. This is not a disputed finding. It is an established biochemical consequence of how statins work.

Why ubiquinol: We use ubiquinol, the active, "ready-to-use" form, because the body's ability to convert standard CoQ10 to ubiquinol declines with age. Our 150mg dose sits within the range used in clinical research.

Rationale:

Qu, H. et al (2018). The effect of statin treatment on circulating coenzyme Q10 concentrations: an updated meta-analysis of randomized controlled trials.European journal of medical research,23(1), 57.

Magnesium participates in over 300 enzymatic reactions in your body, including energy (ATP) production, protein synthesis, and normal muscle and nerve function.* It's also one of the most commonly under-consumed minerals. Roughly 1 in 3 adults falls short, and that tends to worsen with age and certain medications.

Why glycinate: We bind magnesium to the amino acid glycine, which gives it one of the highest bioavailability ratings among magnesium forms and makes it gentler on your stomach than magnesium oxide, the cheapest and most common form found in some other supplements. For something you take every day, that matters. Glycine is an amino acid that also is known for anti-inflammatory properties.

Magnesium has also been associated with improved sleep performance, muscle recovery, migraine support, and joint health support. Magnesium itself has anti-inflammatory properties that can lower C-reactive protein (CRP), an inflammation biomarker often elevated in arthritis sufferers.

Magnesium from your diet can be found in almonds, cashews, leafy greens (like spinach), black beans, soy beans, and whole grains.

Rationale:

Shechter, M. et al. (2000). Oral magnesium therapy improves endothelial function in patients with coronary artery disease.Circulation,102(19), 2353–2358.

Kolte, D., et al (2014). Role of magnesium in cardiovascular diseases.Cardiology in review,22(4), 182–192.

Vitamin D plays a role throughout the body. Its receptors appear in immune cells and many other tissues, yet most adults over 40 are low in it without realizing, especially anyone who spends limited time outdoors.

D3 supports normal immune function and healthy calcium metabolism, and paired with K2 it helps direct calcium toward your bones and away from your arteries.* Low vitamin D levels have been linked in large population studies to poorer heart health — which is exactly why we'd rather you weren't running short.

We use 2,000 IU of D3 (cholecalciferol), a level commonly used to support healthy vitamin D status, and we pair it with K2 because the two work best together.*

Vitamin D3 has also been linked to promoting blood pressure regulation*, mood regulation*, immune system support*, muscle fiber and joint health*, and dental health* (due to it's work with calcium). All in all, D3 is one of our pillar ingredients.

Varzideh, F., et al (2026). Vitamin D in Cardiovascular Medicine: From Molecular Mechanisms to Clinical Translation.Nutrients,18(3), 499.

Gholami, F., Moradi, G., Zareei, B.et al.(2019). The association between circulating 25-hydroxyvitamin D and cardiovascular diseases: a meta-analysis of prospective cohort studies.BMC Cardiovasc Disord19, 248 (2019).

Vitamin K2 activates a protein called Matrix Gla Protein, which helps direct calcium where it belongs — into your bones, and away from your arteries.* It's sometimes called solving the "calcium paradox," and it's the reason we pair K2 with D3. D3 helps you absorb calcium, and K2 helps route it to the right place.

Beyond cardiovascular health, K2 has also been associated with brain and nervous system support*, liver health*, and blood sugar control*.

Form matters: We use MK-7, the form with the best absorption and the longest staying power in the body, so a single daily dose can do its job.*

Important: Vitamin K2 can interact with anticoagulant ("blood thinner") medications, including warfarin. If you take a blood thinner, please talk to your doctor before taking onlyone™ Heart.

Rationale:

Hariri, E., Kassis, N., Iskandar, J. P., et al (2021). Vitamin K2-a neglected player in cardiovascular health: a narrative review.Open heart,8(2), e001715.

Geleijnse, J. M., Vermeer, C., et al (2004). Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study.The Journal of nutrition,134(11), 3100–3105.

These 3 B vitamins are some of the hardest-working nutrients in your body — they help turn the food you eat into usable energy, support a healthy nervous system, and help your body form healthy red blood cells.* They also work together to support methylation, a behind-the-scenes process your body runs around the clock to keep everything ticking over (including keeping homocysteine at healthy levels).* B6, B9, and B12 working together help manage homocysteine levels in the blood*, which has been associated with overall cardiovascular wellness.

Form matters: These three B vitamins work together to support healthy homocysteine metabolism* and we use the active, bioavailable form of each one, so they work effectively regardless of the genetic variations in methylation that affect roughly 40% of people.

• P-5-P is the active form of B6, skipping a conversion step that gets less efficient with age.
• Methylcobalamin is the active form of B12 — which matters because B12 absorption tends to decline after 40.
• 5-MTHF (we use branded Quatrefolic) is the active form of folate (B9), the one your body can use directly even if you carry a common MTHFR variant that makes standard folic acid harder to convert.*

These B vitamins have also been associated with brain and cognitive function support*.

Rationale:

Kataria, N., Yadav, P., Kumar, R., Kumar, N., et al (2021). Effect of Vitamin B6, B9, and B12 Supplementation on Homocysteine Level and Cardiovascular Outcomes in Stroke Patients: A Meta-Analysis of Randomized Controlled Trials.Cureus,13(5), e14958. https://doi.org/10.7759/cureus.14958

Guo, L., Shi, X., Wang, G.et al (2026). Combined B-vitamin supplementation on homocysteine and vascular outcomes in coronary heart disease: a meta-analysis.Annals of medicine,58(1), 2622208. https://doi.org/10.1080/07853890.2026.2622208

Zinc is an essential trace mineral, and like Magnesium is involved in over 300 enzymatic reactions in the body, and it does two things we care about here: it supports normal immune function and acts as a cofactor for superoxide dismutase, one of your body's own antioxidant enzymes.*

Zinc is one of the minerals adults over 40 most often fall short on, especially if you're eating a heart-conscious diet that goes easy on red meat. In other words, the better your eating habits, the easier it is to come up short.

Zinc has also been associated with sensory function, hormone and metabolic support*, and skin health. It's really a pillar nutrient whose benefits may seem invisible, but turn out to be foundational*.

You can find Zinc in red meats, beans, and nuts.

Rationale:

Khazdouz, M., Djalalinia, S., et al (2020). Effects of Zinc Supplementation on Cardiometabolic Risk Factors: a Systematic Review and Meta-analysis of Randomized Controlled Trials.Biological trace element research,195(2), 373–398. https://doi.org/10.1007/s12011-019-01870-9

Pompano, L. M., & Boy, E. (2021). Effects of Dose and Duration of Zinc Interventions on Risk Factors for Type 2 Diabetes and Cardiovascular Disease: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.),12(1), 141–160. https://doi.org/10.1093/advances/nmaa087

Because the gaps that come with statin use and aging aren’t just one thing. CoQ10 gets most of the attention, and it should, but it’s not the only nutrient research shows is affected. Every ingredient in onlyone™ Heart earned its place. We could have kept adding, but we realigned with our core mission which was simplicity and foundational support. If the base needs are not being met, then adding lots of other ingredients would either lower the doses of the existing ingredients or increase the number of capsules you would need to take. Again, simple consistency and foundational support is key. Once you've nailed down your foundational support other things can be added to your routine.

There are many trending heart health herbs and ingredients out there and yes, many may deserve a second look, but first your heart needs its FOUNDATIONAL requirements met. For example: studies have shown that 30% of the population might be magnesium deficient. Since magnesium is used in over 300 enzymatic processes in your body, that cannot be ignored. And a heart health herb is probably not going to fix that foundational deficit. Future products might contain ingredients to help with performance or lipid metabolism, but we will always try to keep to our core mission.

Ubiquinol is the active, reduced form of CoQ10. It’s what your body actually uses. Ubiquinone requires conversion in your cells, a step that becomes less efficient as you age. We use ubiquinol because it’s the better choice, even though it costs us more.

Magnesium glycinate has one of the highest bioavailability ratings among magnesium forms and is significantly gentler on the digestive system than magnesium oxide, the cheapest and most common form. If you’ve had stomach issues with magnesium supplements before, this is why we use glycinate.

See above under specific ingredients FAQ for more information on Magnesium Glycinate.

Vitamin K2 plays a key role in directing calcium appropriately in the body and in supporting vascular health. And it works hand in hand with Vitamin D3 in this role. Note: if you are on Warfarin or another blood thinner, please consult your doctor.

K2 is primarily found in fermented soybeans called Natto. K2 activates Matrix Gla Protein (MGP) which is a powerful protein in your blood vessels linked to preventing soft-tissue calcification.

No. Every ingredient and every dose is disclosed on the label. No hidden amounts, no blends that let some manufacturers use trace amounts and still put something on the label. You deserve to know what you’re putting in your body.

Not all forms of a nutrient are created equal. The synthetic versions in most cheap supplements require conversion steps your body becomes less efficient at performing as you age. We use the active forms throughout to help with any conversion inefficiencies.

Without high bio-availability, your body may excrete much of the nutrient leaving only a fraction for absorption it desperately needs. For B-vitamins this may be have further importance. Approximately 40% of the population may have a gene SNP with their MTHFR gene. This means that they cannot process synthetic forms of B-vitamins, some of which are found in our every day foods such as bread and cereals. Not being able to process these may lead to a nutrient gap, and/or a build up of these synthetics in the blood stream. If you have a discretionary budget for health, or an HSA or FSA Account, we highly recommend the company mygenefood.com to get your full genetic profile. (We are not affiliated with My Gene Food, we simply believe in their mission).

Yes. The nutrients in onlyone™ Heart support healthy body functions. The formula was specifically designed with statin users in mind, but the nutritional gaps it addresses are common in people over 40 generally. As always, consult your doctor before starting any new regimen.