“CoQ10, magnesium, B vitamins, folate, and K2 contribute to processes that matter for cardiovascular health. The combination is the point.”

Julia ZumpanoRegistered Dietitian, Cleveland Clinic

onlyone™ Heart

Daily 8-in-1 cardiovascular support for adults using cholesterol-lowering therapy such as statins. Two capsules, once daily.

Key benefits

Cellular energy: supports natural energy production.*
Heart muscle: supports healthy performance and comfort.*
Blood pressure: supports levels already in the normal range.*
Homocysteine metabolism: supports healthy methylation.*

“CoQ10, magnesium, B vitamins, folate, and K2 contribute to processes that matter for cardiovascular health. The combination is the point.”

Julia ZumpanoRegistered Dietitian, Cleveland Clinic

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One-time, 30-day supply

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Why choose onlyone™ Heart

Third-party tested

GMP-certified quality

No artificial fillers

Adults using cholesterol-lowering medications like statins who want targeted, daily nutritional support for their heart. It's designed to work alongside the care your doctor prescribes, not replace it.*

It may be especially relevant if you want to support healthy energy levels, a healthy inflammatory response, muscle performance, and long-term vitality as you age.*

Most of my patients on cardiac medications are already managing a lot. Consolidating the key nutrients into one daily routine rather than five or six separate bottles is a meaningful step toward consistency. And consistency is what makes the difference.

Julia Zumpano Cardiac Dietitian, Cleveland Clinic

Cellular energy: supports natural energy production and cellular energy metabolism.*
Arterial support: supports a normal inflammatory response and healthy calcium routing.*
Heart muscle and rhythm: supports healthy heart-muscle performance and comfort.*
Cardiovascular wellness: supports healthy blood pressure levels already within the normal range.*
Methylation: active B vitamins support healthy homocysteine metabolism.*
Healthy aging: supports sustained vitality and long-term wellness.*

Free U.S. shipping No extra shipping cost on your order.

60-day easy refunds If it isn't right for you, you have 60 days to request a refund.

Not sure it's the right fit? Give it the 60 days most supplements need to build up. If it isn't working for you, the refund window gives you a clear way out.

Read the full refund policy

Shipping policy

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

onlyone™ Heart

$69.00

Stephen, founderWhy he created onlyone™ Heart

For people already taking care of their heart

Doing everything right, but still feel like something's missing?

You take your medication. You watch what you eat. You stay active. But supporting heart health can involve more than managing cholesterol alone.*

Stay consistent. Support the routine you already follow every day.
Support steady energy. Help cover the nutrients involved in cellular energy.*
Support heart function. Target nutrients involved in healthy cardiovascular function.*

That's the gap Stephen wanted to close.

After managing his own cardiovascular health alongside statin therapy, Stephen wanted a simpler way to support the nutritional needs surrounding that daily routine.

onlyone™ Heart: 2 capsules once daily, with targeted nutrients designed to complement your heart-health routine.*

See how onlyone™ Heart helps

2 capsules once dailySimple format, clear routine

8 targeted nutrientsBuilt around heart health

60-day easy refundsLess risk to try it

Daily heart support

How onlyone™ Heart supports daily heart health.

A research-led blend of eight nutrients designed to support key aspects of cardiovascular health.*

Supports cellular energy

Helps support mitochondrial energy production involved in daily heart function.*

Defense & resilience

Supports a healthy inflammatory response and antioxidant defense.*

Supports vascular tone

Supports muscle relaxation and electrolyte balance involved in heart function.*

Supports healthy homocysteine metabolism

Supports normal methylation and helps maintain homocysteine levels already within the normal range.*

Supports vascular function

Supports healthy calcium routing and vascular health.*

Everything in one place, for a reason.

Eight nutrients. More than one job each.

Calm & rest

Supports muscle relaxation, normal nervous-system function, and healthy sleep cycles.*

Magnesium glycinate

Mental sharpness

Supports normal cognitive function and healthy nerve signaling.*

B12FolateB6

Bone support

D3 helps you absorb calcium, K2 directs it toward bone, and magnesium helps put it to use.*

Vitamin D3K2Magnesium

Immune defense

Supports normal immune function.*

ZincVitamin D3

Blood & oxygen

Supports normal red blood cell formation, which is how oxygen reaches the rest of your body.*

B12Folate

Inflammatory balance

Supports a healthy inflammatory response.*

Zinc

Two capsules a day. Here's how to make it stick.

Take 2 capsules once daily with food and water.
A single daily serving keeps things simple from the start.
Pair it with a habit you already have.
Breakfast, your morning pills, or your first glass of water.
Keep it simple and stick with it.
One formula, one habit. Give it 60 to 90 days of consistent use.

My patients frequently ask about nutritional support when managing cardiovascular health. A formulation that combines commonly discussed ingredients such as CoQ10, magnesium, and B vitamins into a single product simplifies supplementation and may ease the pill burden many of our patients deal with.

Dr. Danny EapenBoard-certified cardiologist

What's inside

Eight nutrients. A clear reason for each one.

See each ingredient, its dose, and why it's there. Open any one for the details.

CoQ10150 mg

Cellular energy, heart-muscle support

Form: ubiquinol, the active form your body can use right away. Statins can lower your body's own CoQ10 production because they affect the same pathway used to make it.*

Magnesium125 mg

Muscle function, relaxation

Form: magnesium glycinate, well absorbed and gentle on the stomach. Levels can decline with age, and many adults over 40 may not be getting enough.*

Zinc10 mg

Immune defense, healthy inflammatory response

Form: zinc bisglycinate chelate.Zinc helps your antioxidant enzymes work. Intake often drops with age, especially on heart-healthy diets.*

Vitamin B62 mg

Homocysteine metabolism, energy

Form: P-5-P, (pyridoxal-5-phosphate), the active form. Works with B12 and folate to help keep homocysteine in its normal range.*

Vitamin B12400 mcg

Mental sharpness, red blood cells

Form: methylcobalamin, an active form. Supports normal nerve function and red blood cell formation.*

Folate500 mcg DFE

Homocysteine metabolism, cell renewal

Form: Quatrefolic® (5-MTHF), the active form of folate, so your body doesn't have to convert it first.*

Vitamin D32,000 IU

Calcium absorption, immune function

Form: cholecalciferol. Supports calcium regulation, immune function, and normal muscle function. Paired with K2 so calcium ends up where it's needed.*

Vitamin K2100 mcg

Calcium routing, healthy arteries

Form: MK-7, the most bioavailable form.*

Taking warfarin or another blood thinner? Talk to your doctor before use.

Nothing hidden. Every dose on the label.

No proprietary blends
Third-party tested
Made in the USA, GMP-certified
Vegan and cruelty-free

Shop onlyone™ Heart

Supplement Facts

Serving size: 2 capsules
Servings per container: 30

Nutrient	Amount per serving
CoQ10as ubiquinol	150 mg
Magnesiumas magnesium glycinate	125 mg
Zincas zinc bisglycinate chelate	10 mg
Vitamin B6as pyridoxal-5-phosphate	2 mg
Vitamin B12as methylcobalamin	400 mcg
Folateas Quatrefolic® (5-MTHF)	500 mcg DFE
Vitamin D3as cholecalciferol	2,000 IU
Vitamin K2as MK-7 (menaquinone-7)	100 mcg

Other ingredients:

vegetable capsule, plant-derived excipients.

If you take warfarin or another blood thinner, consult your doctor before use.

Still have questions?

Honest answers to what people ask us most.

We're pro-doctor.

If you take prescription medications, bring your questions to your cardiologist too. Or contact us

Will this interfere with my statin or other medications?

onlyone™ Heart is designed to work alongside your statin therapy, not replace or interfere with it. If you have specific concerns, run it by your cardiologist first.

Always check with your physician before starting a new supplement, especially if you take other prescription medications. If you're on a blood thinner such as warfarin, talk to your doctor about the vitamin K2 content. We use MK-7, not the K1 form with known warfarin interactions, but your doctor should be comfortable with it.*

Why ubiquinol instead of ubiquinone?

Ubiquinol is the active form of CoQ10. Research suggests it's better absorbed, particularly for people over 40, whose bodies become less efficient at converting ubiquinone into the usable form.* It costs more. We use it anyway.

When will I start noticing a difference?

Everyone is different, and we don't promise specific outcomes. onlyone™ Heart is a dietary supplement, not a drug. Most supplements take several weeks to build up and support normal body functions over time.

We recommend giving it at least 60 to 90 days, which is why we offer 60-day easy refunds.

Why is Methylation status relelevant to heart health?

Methylation is one of your body's most important behind-the-scenes processes — a constant chemical hand-off that happens billions of times a second, helping your body do everything from building DNA to processing certain compounds and keeping key systems running smoothly.* B vitamins (B6, B9/folate, and B12) are essential helpers in this process.

Homocysteine is an amino acid your body produces normally as a byproduct of metabolizing methionine (an amino acid from protein in your diet). It's not meant to accumulate; your body continuously clears it through two pathways, and methylation is the main one.

Adequate active B vitamins keep the methylation pathway running, which is how the body maintains homocysteine in its normal range.

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I am not a good sleeper, since starting only one Heart, I am sleeping much better. In general my energy level has definitely improved. I’m very happy to be adding this to my regular schedule.

I have been on statins for over 20 years plus lots of other piils and supplements. only one Heart has definitely made my mornnig pill routine simpler and easier and i already feel more energetic!

Am I crazy or what? I have only been taking Only One Heart capsules for two weeks and already I am feeling results! I am sleeping much more soundly and waking feeling refreshed and not that old “still tired” sensation. I am 81 years old and in the past needed an hour or two nap mid day. I don’t feel I need that now. I have much more energy all day. I can’t wait to see my results after a full month and beyond!

I've been on a statin for years and wanted to support my heart better. This gives me the confidence that I'm doing the right thing everyday.

Perfect companion for my statin medication
I recently started taking this specifically to help with the muscle fatigue caused by my cholesterol medication. The 150mg of Ubiquinol CoQ10 has made a noticeable difference in how my body feels. High-quality ingredients and zero stomach upset.

Before onlyone Heart, I was taking six to eight different supplement pills a day. Having a quality combination in just two capsules has made my routine far easier. After the first week, I also noticed a significant boost in my energy, both physically and mentally.

I forgot to pack onlyone Heart for a five-day trip, and NOT taking them was noticeable. I didn't sleep as well, and I wasn't even looking for a difference. I'm going to keep taking them. Big fan!

Good product

Excellent product. Great energy throughout the day when taken in morning. Look forward to taking this daily

Excellent product but amount per serving for vit D3, coQ10 and vitamin k2 should be higher.

So grateful to have onlyone Heart post so many heart diagnoses and info to help on the road to recovery.

Wonderful and grateful to have onlyoneheart post many heart diagnoses to help on the road to recovery.

Just received recently and finishing previous medicines already set up but looking forward to starting it soon as it replaces severel supplements we are already taking

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Practical, research-backed guidance on heart health, supplements, and the questions that come up when you're taking better care of yourself.

Plain-language guidance without medical jargon
Heart-health tips you can actually act on
Research made easier to understand

onlyone™ Heart

Key benefits

Why choose onlyone™ Heart

Doing everything right, but still feel like something's missing?

How onlyone™ Heart supports daily heart health.

Supports cellular energy

Defense & resilience

Supports vascular tone

Supports healthy homocysteine metabolism

Supports vascular function

Everything in one place, for a reason.

Calm & rest

Mental sharpness

Bone support

Immune defense

Blood & oxygen

Inflammatory balance

Two capsules a day. Here's how to make it stick.

Take 2 capsules once daily with food and water.

Pair it with a habit you already have.

Keep it simple and stick with it.

Eight nutrients. A clear reason for each one.

Nothing hidden. Every dose on the label.

Still have questions?

Heart health, explained simply.

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